Protein conformations studied at single molecule level

Proteins can be viewed as nano-machines with moving elements. We are studying the link between conformational changes that a folded protein undergoes and its functionality at high temporal resolution.
The model molecule presently used for this study is the E. Coli Adenylate kinase; a multi-domain enzyme molecule.
The research is performed at the single molecule level in high temporal resolution achieved by applying different fluorescence techniques such as FRET and FCS. The project is done as a collaboration with Haas’ group.

Adenylate kinase

Adenylate kinase