Eldad Kepten

Eldad KeptenDepartment of Physics,
Bar-Ilan University,
Ramat Gan 5290002, Israel
Phone: +972-3-531-7393
Fax: +972-3-738-4054
E-mail

Education

2015 – Ph.D. in Physics, Bar-Ilan University, Israel
2006 – B.Sc. in Physics and Mathematics, The Hebrew University of Jerusalem, Israel

Research Overview

I see physics as the ultimate way of understanding nature and appreciating its deepest beauty. In my personal opinion, the field in which present day science faces its greatest challenges is the description and understanding of biological processes. In most physical fields we have a fair understanding of at least the first few levels of detail and approximation. In biology on the other hand, we are far from obtaining a clear picture of what truly controls and directs even the simplest cell, let alone an organism. Thus after a few years in somewhat ‘mechanical’ physics (ballistics and penetration dynamics), I have turned to the study of live cell biophysics.
My research is focused around the question of chromatin organization in the cell nucleus. This project demands the incorporation of in vivo fluorescent microscopy with advanced analysis of stochastic data and analytic physical modeling. For me, this combination of messy, ‘hands on’ biology together with ‘clean’ physical modeling is a modern day manifestation of basic science.
To learn more about this project, click on the link below or go to our projects page. To ask any questions (or join us!) send me an email.

Studying the nuclear environment through chromatin diffusion

Major Publications

  1. I. Bronshtein*, E. Kepten*, I. Kanter, S. Berezin, M. Lindner, A. B. Redwood, S. Mai, S. Gonzalo, R. Foisner, Y. Shav-Tal and Y. Garini, Loss of lamin A function increases chromatin dynamics in the nuclear interior. Nature Communications, 6, 8044 (2015). *Equal contribution
  2. E. Kepten, A. Weron, I. Bronshtein, K. Burnecki and Y. Garini, Hubble diffusion description of distance dependent anisotropic chromatin motion. Biophysical Journal, In Review (2015)
  3. K. Burnecki, E. Kepten, Y. Garini, G. Sikora and A. Weron, Estimating the anomalous diffusion exponent for single particle tracking data with measurement errors – An alternative approach. Scientific Reports, Accepted (2015)
  4. E. Kepten, A. Weron, G. Sikora, K. Burnecki and Y. Garini, Guidelines for the fitting of anomalous diffusion mean square displacement graphs from single particle tracking experiments. PLoS ONE 10(2): e0117722 (2015).
  5. E. Kepten, I. Bronshtein and Y. Garini, Improved estimation of anomalous diffusion exponents in single-particle tracking experiments. Physical Review E 87, 052713 (2013).
  6. I. Bronshtein, E. Kepten, and Y. Garini, Single Particle Tracking for Studying the Dynamic Properties of Genomic Regions in Live Cells. Methods in Molecular Biology, Vol. 1042 (2013), Shav-Tal, Yaron (Ed.), Springer
  7. K. Burnecki, E. Kepten, J. Janczura, I. Bronshtein, Y. Garini and A. Weron, Universal Algorithm for Identification of Fractional Brownian Motion. A Case of Telomere Subdiffusion. Biophysical Journal 103(9), 1839-1847 (2012).
  8. E. Kepten, I. Bronshtein and Y. Garini, Ergodicity convergence test suggests telomere motion obeys fractional dynamics. Physical Review E 83, 041919 (2011).
  9. I. Bronstein Berger, Y. Israel, E. Kepten, S. Mai, Y. Shav-Tal, E. Barkai and Y. Garini, Transient anomalous diffusion of telomeres in the nucleus of mammalian cells. Physical Review Letters 103, 018102 (2009).